Flight 7500 departs Los Angeles International Airport bound for Tokyo. As the overnight flight makes its way over the Pacific Ocean during its ten-hour course, the passengers encounter what appears to be a supernatural force in the cabin.
When Allyson Simon separates from her husband and moves with their 9 year old daughter Claire to a big old house in the country, she learns of a brutal family murder that happened there five years ago.
Two best friends see their trip of a lifetime take a dark turn when one of them is struck by a mysterious affliction. Now, in a foreign land, they race to uncover the source before it consumes him completely.
Anna, a single mum, and local pariah, receives little help from the authorities when her daughter goes missing. It soon becomes apparent however, that it's not just Anna's child that is missing; all the children in her small town have disappeared.